WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for the enriched GO category are listed in this table. For each GO category, the first row lists its sub-root (biological process, molecular function, or cellular component), category name, and corresponding GO ID.
The second row lists the following statistics:
Finally, genes in the category are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:biological process       Name:regulation of myeloid cell differentiation       ID:GO:0045637
C=128; O=6; E=0.66; R=9.14; rawP=4.90e-05; adjP=0.0337
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000197372 NA ZNF675 zinc finger protein 675 171392 ENSG00000197372
2  ENSG00000049130 NA KITLG KIT ligand 4254 ENSG00000049130
3  ENSG00000135363 NA LMO2 LIM domain only 2 (rhombotin-like 1) 4005 ENSG00000135363
4  ENSG00000109906 NA ZBTB16 zinc finger and BTB domain containing 16 7704 ENSG00000109906
5  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689
6  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864


Database:biological process       Name:myeloid cell differentiation       ID:GO:0030099
C=240; O=7; E=1.23; R=5.69; rawP=0.0002; adjP=0.0343
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000197372 NA ZNF675 zinc finger protein 675 171392 ENSG00000197372
2  ENSG00000049130 NA KITLG KIT ligand 4254 ENSG00000049130
3  ENSG00000135363 NA LMO2 LIM domain only 2 (rhombotin-like 1) 4005 ENSG00000135363
4  ENSG00000152804 NA HHEX hematopoietically expressed homeobox 3087 ENSG00000152804
5  ENSG00000109906 NA ZBTB16 zinc finger and BTB domain containing 16 7704 ENSG00000109906
6  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689
7  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864


Database:biological process       Name:hemopoiesis       ID:GO:0030097
C=498; O=10; E=2.55; R=3.92; rawP=0.0002; adjP=0.0343
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000197372 NA ZNF675 zinc finger protein 675 171392 ENSG00000197372
2  ENSG00000152804 NA HHEX hematopoietically expressed homeobox 3087 ENSG00000152804
3  ENSG00000109906 NA ZBTB16 zinc finger and BTB domain containing 16 7704 ENSG00000109906
4  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864
5  ENSG00000171522 NA PTGER4 prostaglandin E receptor 4 (subtype EP4) 5734 ENSG00000171522
6  ENSG00000049130 NA KITLG KIT ligand 4254 ENSG00000049130
7  ENSG00000099875 NA MKNK2 MAP kinase interacting serine/threonine kinase 2 2872 ENSG00000099875
8  ENSG00000135363 NA LMO2 LIM domain only 2 (rhombotin-like 1) 4005 ENSG00000135363
9  ENSG00000163659 NA TIPARP TCDD-inducible poly(ADP-ribose) polymerase 25976 ENSG00000163659
10  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689


Database:biological process       Name:negative regulation of myeloid cell differentiation       ID:GO:0045638
C=56; O=4; E=0.29; R=13.93; rawP=0.0002; adjP=0.0343
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000197372 NA ZNF675 zinc finger protein 675 171392 ENSG00000197372
2  ENSG00000135363 NA LMO2 LIM domain only 2 (rhombotin-like 1) 4005 ENSG00000135363
3  ENSG00000109906 NA ZBTB16 zinc finger and BTB domain containing 16 7704 ENSG00000109906
4  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864


Database:biological process       Name:hematopoietic or lymphoid organ development       ID:GO:0048534
C=532; O=10; E=2.73; R=3.67; rawP=0.0004; adjP=0.0550
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000197372 NA ZNF675 zinc finger protein 675 171392 ENSG00000197372
2  ENSG00000152804 NA HHEX hematopoietically expressed homeobox 3087 ENSG00000152804
3  ENSG00000109906 NA ZBTB16 zinc finger and BTB domain containing 16 7704 ENSG00000109906
4  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864
5  ENSG00000171522 NA PTGER4 prostaglandin E receptor 4 (subtype EP4) 5734 ENSG00000171522
6  ENSG00000049130 NA KITLG KIT ligand 4254 ENSG00000049130
7  ENSG00000099875 NA MKNK2 MAP kinase interacting serine/threonine kinase 2 2872 ENSG00000099875
8  ENSG00000135363 NA LMO2 LIM domain only 2 (rhombotin-like 1) 4005 ENSG00000135363
9  ENSG00000163659 NA TIPARP TCDD-inducible poly(ADP-ribose) polymerase 25976 ENSG00000163659
10  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689


Database:biological process       Name:interkinetic nuclear migration       ID:GO:0022027
C=7; O=2; E=0.04; R=55.73; rawP=0.0005; adjP=0.0573
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000152804 NA HHEX hematopoietically expressed homeobox 3087 ENSG00000152804
2  ENSG00000147526 NA TACC1 transforming, acidic coiled-coil containing protein 1 6867 ENSG00000147526


Database:biological process       Name:immune system development       ID:GO:0002520
C=564; O=10; E=2.89; R=3.46; rawP=0.0006; adjP=0.0589
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000197372 NA ZNF675 zinc finger protein 675 171392 ENSG00000197372
2  ENSG00000152804 NA HHEX hematopoietically expressed homeobox 3087 ENSG00000152804
3  ENSG00000109906 NA ZBTB16 zinc finger and BTB domain containing 16 7704 ENSG00000109906
4  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864
5  ENSG00000171522 NA PTGER4 prostaglandin E receptor 4 (subtype EP4) 5734 ENSG00000171522
6  ENSG00000049130 NA KITLG KIT ligand 4254 ENSG00000049130
7  ENSG00000099875 NA MKNK2 MAP kinase interacting serine/threonine kinase 2 2872 ENSG00000099875
8  ENSG00000135363 NA LMO2 LIM domain only 2 (rhombotin-like 1) 4005 ENSG00000135363
9  ENSG00000163659 NA TIPARP TCDD-inducible poly(ADP-ribose) polymerase 25976 ENSG00000163659
10  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689


Database:biological process       Name:system development       ID:GO:0048731
C=3521; O=31; E=18.05; R=1.72; rawP=0.0007; adjP=0.0601
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000150630 NA VEGFC vascular endothelial growth factor C 7424 ENSG00000150630
2  ENSG00000197372 NA ZNF675 zinc finger protein 675 171392 ENSG00000197372
3  ENSG00000189184 NA PCDH18 protocadherin 18 54510 ENSG00000189184
4  ENSG00000109906 NA ZBTB16 zinc finger and BTB domain containing 16 7704 ENSG00000109906
5  ENSG00000147526 NA TACC1 transforming, acidic coiled-coil containing protein 1 6867 ENSG00000147526
6  ENSG00000168329 NA CX3CR1 chemokine (C-X3-C motif) receptor 1 1524 ENSG00000168329
7  ENSG00000171522 NA PTGER4 prostaglandin E receptor 4 (subtype EP4) 5734 ENSG00000171522
8  ENSG00000113532 NA ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 7903 ENSG00000113532
9  ENSG00000135363 NA LMO2 LIM domain only 2 (rhombotin-like 1) 4005 ENSG00000135363
10  ENSG00000171552 NA BCL2L1 BCL2-like 1 598 ENSG00000171552
11  ENSG00000142973 NA CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 1580 ENSG00000142973
12  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689
13  ENSG00000138386 NA NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 4664 ENSG00000138386
14  ENSG00000175866 NA BAIAP2 BAI1-associated protein 2 10458 ENSG00000175866
15  ENSG00000178860 NA MSC musculin 9242 ENSG00000178860
16  ENSG00000152804 NA HHEX hematopoietically expressed homeobox 3087 ENSG00000152804
17  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864
18  ENSG00000165959 NA CLMN calmin (calponin-like, transmembrane) 79789 ENSG00000165959
19  ENSG00000116584 NA ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 9181 ENSG00000116584
20  ENSG00000099875 NA MKNK2 MAP kinase interacting serine/threonine kinase 2 2872 ENSG00000099875
21  ENSG00000163884 NA KLF15 Kruppel-like factor 15 28999 ENSG00000163884
22  ENSG00000049130 NA KITLG KIT ligand 4254 ENSG00000049130
23  ENSG00000151702 NA FLI1 Friend leukemia virus integration 1 2313 ENSG00000151702
24  ENSG00000134323 NA MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 4613 ENSG00000134323
25  ENSG00000107859 NA PITX3 paired-like homeodomain 3 5309 ENSG00000107859
26  ENSG00000163659 NA TIPARP TCDD-inducible poly(ADP-ribose) polymerase 25976 ENSG00000163659
27  ENSG00000136872 NA ALDOB aldolase B, fructose-bisphosphate 229 ENSG00000136872
28  ENSG00000105851 NA PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 5294 ENSG00000105851
29  ENSG00000064999 NA ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 23294 ENSG00000064999
30  ENSG00000113594 NA LIFR leukemia inhibitory factor receptor alpha 3977 ENSG00000113594
31  ENSG00000095015 NA MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 4214 ENSG00000095015


Database:biological process       Name:death       ID:GO:0016265
C=1706; O=18; E=8.75; R=2.06; rawP=0.0020; adjP=0.0859
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163947 NA ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 50650 ENSG00000163947
2  ENSG00000115363 NA FAM176A family with sequence similarity 176, member A 84141 ENSG00000115363
3  ENSG00000109906 NA ZBTB16 zinc finger and BTB domain containing 16 7704 ENSG00000109906
4  ENSG00000168329 NA CX3CR1 chemokine (C-X3-C motif) receptor 1 1524 ENSG00000168329
5  ENSG00000177374 NA HIC1 hypermethylated in cancer 1 3090 ENSG00000177374
6  ENSG00000171552 NA BCL2L1 BCL2-like 1 598 ENSG00000171552
7  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689
8  ENSG00000077684 NA PHF17 PHD finger protein 17 79960 ENSG00000077684
9  ENSG00000145632 NA PLK2 polo-like kinase 2 10769 ENSG00000145632
10  ENSG00000126217 NA MCF2L MCF.2 cell line derived transforming sequence-like 23263 ENSG00000126217
11  ENSG00000049130 NA KITLG KIT ligand 4254 ENSG00000049130
12  ENSG00000099875 NA MKNK2 MAP kinase interacting serine/threonine kinase 2 2872 ENSG00000099875
13  ENSG00000116584 NA ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 9181 ENSG00000116584
14  ENSG00000166289 NA PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 79156 ENSG00000166289
15  ENSG00000134323 NA MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 4613 ENSG00000134323
16  ENSG00000105851 NA PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 5294 ENSG00000105851
17  ENSG00000003400 NA CASP10 caspase 10, apoptosis-related cysteine peptidase 843 ENSG00000003400
18  ENSG00000095015 NA MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 4214 ENSG00000095015


Database:biological process       Name:apoptotic process       ID:GO:0006915
C=1528; O=17; E=7.83; R=2.17; rawP=0.0016; adjP=0.0859
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163947 NA ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 50650 ENSG00000163947
2  ENSG00000115363 NA FAM176A family with sequence similarity 176, member A 84141 ENSG00000115363
3  ENSG00000109906 NA ZBTB16 zinc finger and BTB domain containing 16 7704 ENSG00000109906
4  ENSG00000168329 NA CX3CR1 chemokine (C-X3-C motif) receptor 1 1524 ENSG00000168329
5  ENSG00000177374 NA HIC1 hypermethylated in cancer 1 3090 ENSG00000177374
6  ENSG00000171552 NA BCL2L1 BCL2-like 1 598 ENSG00000171552
7  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689
8  ENSG00000077684 NA PHF17 PHD finger protein 17 79960 ENSG00000077684
9  ENSG00000145632 NA PLK2 polo-like kinase 2 10769 ENSG00000145632
10  ENSG00000126217 NA MCF2L MCF.2 cell line derived transforming sequence-like 23263 ENSG00000126217
11  ENSG00000049130 NA KITLG KIT ligand 4254 ENSG00000049130
12  ENSG00000099875 NA MKNK2 MAP kinase interacting serine/threonine kinase 2 2872 ENSG00000099875
13  ENSG00000116584 NA ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 9181 ENSG00000116584
14  ENSG00000166289 NA PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 79156 ENSG00000166289
15  ENSG00000105851 NA PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 5294 ENSG00000105851
16  ENSG00000003400 NA CASP10 caspase 10, apoptosis-related cysteine peptidase 843 ENSG00000003400
17  ENSG00000095015 NA MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 4214 ENSG00000095015


Database:molecular function       Name:Rho guanyl-nucleotide exchange factor activity       ID:GO:0005089
C=75; O=4; E=0.36; R=11.17; rawP=0.0005; adjP=0.0270
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000116584 NA ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 9181 ENSG00000116584
2  ENSG00000163947 NA ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 50650 ENSG00000163947
3  ENSG00000126217 NA MCF2L MCF.2 cell line derived transforming sequence-like 23263 ENSG00000126217
4  ENSG00000088387 NA DOCK9 dedicator of cytokinesis 9 23348 ENSG00000088387


Database:molecular function       Name:phospholipid binding       ID:GO:0005543
C=490; O=9; E=2.34; R=3.85; rawP=0.0005; adjP=0.0270
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000144909 NA OSBPL11 oxysterol binding protein-like 11 114885 ENSG00000144909
2  ENSG00000163947 NA ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 50650 ENSG00000163947
3  ENSG00000126217 NA MCF2L MCF.2 cell line derived transforming sequence-like 23263 ENSG00000126217
4  ENSG00000136044 NA APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 55198 ENSG00000136044
5  ENSG00000116584 NA ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 9181 ENSG00000116584
6  ENSG00000166289 NA PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 79156 ENSG00000166289
7  ENSG00000133056 NA PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 5287 ENSG00000133056
8  ENSG00000136872 NA ALDOB aldolase B, fructose-bisphosphate 229 ENSG00000136872
9  ENSG00000088387 NA DOCK9 dedicator of cytokinesis 9 23348 ENSG00000088387


Database:molecular function       Name:lipid binding       ID:GO:0008289
C=742; O=10; E=3.54; R=2.82; rawP=0.0027; adjP=0.0378
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000144909 NA OSBPL11 oxysterol binding protein-like 11 114885 ENSG00000144909
2  ENSG00000163947 NA ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 50650 ENSG00000163947
3  ENSG00000126217 NA MCF2L MCF.2 cell line derived transforming sequence-like 23263 ENSG00000126217
4  ENSG00000136044 NA APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 55198 ENSG00000136044
5  ENSG00000116584 NA ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 9181 ENSG00000116584
6  ENSG00000166289 NA PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 79156 ENSG00000166289
7  ENSG00000133056 NA PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 5287 ENSG00000133056
8  ENSG00000136872 NA ALDOB aldolase B, fructose-bisphosphate 229 ENSG00000136872
9  ENSG00000088387 NA DOCK9 dedicator of cytokinesis 9 23348 ENSG00000088387
10  ENSG00000095015 NA MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 4214 ENSG00000095015


Database:molecular function       Name:binding       ID:GO:0005488
C=11955; O=67; E=57.10; R=1.17; rawP=0.0018; adjP=0.0378
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000118946 NA PCDH17 protocadherin 17 27253 ENSG00000118946
2  ENSG00000171552 NA BCL2L1 BCL2-like 1 598 ENSG00000171552
3  ENSG00000138386 NA NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 4664 ENSG00000138386
4  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864
5  ENSG00000155130 NA MARCKS myristoylated alanine-rich protein kinase C substrate 4082 ENSG00000155130
6  ENSG00000163659 NA TIPARP TCDD-inducible poly(ADP-ribose) polymerase 25976 ENSG00000163659
7  ENSG00000003400 NA CASP10 caspase 10, apoptosis-related cysteine peptidase 843 ENSG00000003400
8  ENSG00000144063 NA MALL mal, T-cell differentiation protein-like 7851 ENSG00000144063
9  ENSG00000109906 NA ZBTB16 zinc finger and BTB domain containing 16 7704 ENSG00000109906
10  ENSG00000171522 NA PTGER4 prostaglandin E receptor 4 (subtype EP4) 5734 ENSG00000171522
11  ENSG00000142733 NA MAP3K6 mitogen-activated protein kinase kinase kinase 6 9064 ENSG00000142733
12  ENSG00000077684 NA PHF17 PHD finger protein 17 79960 ENSG00000077684
13  ENSG00000152804 NA HHEX hematopoietically expressed homeobox 3087 ENSG00000152804
14  ENSG00000178860 NA MSC musculin 9242 ENSG00000178860
15  ENSG00000145632 NA PLK2 polo-like kinase 2 10769 ENSG00000145632
16  ENSG00000049130 NA KITLG KIT ligand 4254 ENSG00000049130
17  ENSG00000163884 NA KLF15 Kruppel-like factor 15 28999 ENSG00000163884
18  ENSG00000161647 NA MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 4356 ENSG00000161647
19  ENSG00000096060 NA FKBP5 FK506 binding protein 5 2289 ENSG00000096060
20  ENSG00000133056 NA PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 5287 ENSG00000133056
21  ENSG00000136872 NA ALDOB aldolase B, fructose-bisphosphate 229 ENSG00000136872
22  ENSG00000103037 NA SETD6 SET domain containing 6 79918 ENSG00000103037
23  ENSG00000092068 NA SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 23428 ENSG00000092068
24  ENSG00000064999 NA ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 23294 ENSG00000064999
25  ENSG00000113594 NA LIFR leukemia inhibitory factor receptor alpha 3977 ENSG00000113594
26  ENSG00000124440 NA HIF3A hypoxia inducible factor 3, alpha subunit 64344 ENSG00000124440
27  ENSG00000189184 NA PCDH18 protocadherin 18 54510 ENSG00000189184
28  ENSG00000163947 NA ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 50650 ENSG00000163947
29  ENSG00000168329 NA CX3CR1 chemokine (C-X3-C motif) receptor 1 1524 ENSG00000168329
30  ENSG00000181915 NA ADO 2-aminoethanethiol (cysteamine) dioxygenase 84890 ENSG00000181915
31  ENSG00000006831 NA ADIPOR2 adiponectin receptor 2 79602 ENSG00000006831
32  ENSG00000113532 NA ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 7903 ENSG00000113532
33  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689
34  ENSG00000142973 NA CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 1580 ENSG00000142973
35  ENSG00000161896 NA IP6K3 inositol hexakisphosphate kinase 3 117283 ENSG00000161896
36  ENSG00000126217 NA MCF2L MCF.2 cell line derived transforming sequence-like 23263 ENSG00000126217
37  ENSG00000112576 NA CCND3 cyclin D3 896 ENSG00000112576
38  ENSG00000099875 NA MKNK2 MAP kinase interacting serine/threonine kinase 2 2872 ENSG00000099875
39  ENSG00000116584 NA ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 9181 ENSG00000116584
40  ENSG00000166289 NA PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 79156 ENSG00000166289
41  ENSG00000151702 NA FLI1 Friend leukemia virus integration 1 2313 ENSG00000151702
42  ENSG00000203942 NA C10orf62 chromosome 10 open reading frame 62 414157 ENSG00000203942
43  ENSG00000134323 NA MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 4613 ENSG00000134323
44  ENSG00000095015 NA MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 4214 ENSG00000095015
45  ENSG00000136870 NA ZNF189 zinc finger protein 189 7743 ENSG00000136870
46  ENSG00000197372 NA ZNF675 zinc finger protein 675 171392 ENSG00000197372
47  ENSG00000150630 NA VEGFC vascular endothelial growth factor C 7424 ENSG00000150630
48  ENSG00000135338 NA LCA5 Leber congenital amaurosis 5 167691 ENSG00000135338
49  ENSG00000171970 NA ZNF57 zinc finger protein 57 126295 ENSG00000171970
50  ENSG00000147526 NA TACC1 transforming, acidic coiled-coil containing protein 1 6867 ENSG00000147526
51  ENSG00000135363 NA LMO2 LIM domain only 2 (rhombotin-like 1) 4005 ENSG00000135363
52  ENSG00000177374 NA HIC1 hypermethylated in cancer 1 3090 ENSG00000177374
53  ENSG00000197566 NA ZNF624 zinc finger protein 624 57547 ENSG00000197566
54  ENSG00000181004 NA BBS12 Bardet-Biedl syndrome 12 166379 ENSG00000181004
55  ENSG00000047597 NA XK X-linked Kx blood group (McLeod syndrome) 7504 ENSG00000047597
56  ENSG00000175866 NA BAIAP2 BAI1-associated protein 2 10458 ENSG00000175866
57  ENSG00000142599 NA RERE arginine-glutamic acid dipeptide (RE) repeats 473 ENSG00000142599
58  ENSG00000144909 NA OSBPL11 oxysterol binding protein-like 11 114885 ENSG00000144909
59  ENSG00000094963 NA FMO2 flavin containing monooxygenase 2 (non-functional) 2327 ENSG00000094963
60  ENSG00000205268 NA PDE7A phosphodiesterase 7A 5150 ENSG00000205268
61  ENSG00000136044 NA APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 55198 ENSG00000136044
62  ENSG00000110042 NA DTX4 deltex homolog 4 (Drosophila) 23220 ENSG00000110042
63  ENSG00000028839 NA TBPL1 TBP-like 1 9519 ENSG00000028839
64  ENSG00000165959 NA CLMN calmin (calponin-like, transmembrane) 79789 ENSG00000165959
65  ENSG00000107859 NA PITX3 paired-like homeodomain 3 5309 ENSG00000107859
66  ENSG00000105851 NA PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 5294 ENSG00000105851
67  ENSG00000088387 NA DOCK9 dedicator of cytokinesis 9 23348 ENSG00000088387


Database:molecular function       Name:phosphatidylinositol 3-kinase activity       ID:GO:0035004
C=13; O=2; E=0.06; R=32.21; rawP=0.0017; adjP=0.0378
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000133056 NA PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 5287 ENSG00000133056
2  ENSG00000105851 NA PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 5294 ENSG00000105851


Database:molecular function       Name:sequence-specific DNA binding transcription factor activity       ID:GO:0003700
C=1009; O=12; E=4.82; R=2.49; rawP=0.0028; adjP=0.0378
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000152804 NA HHEX hematopoietically expressed homeobox 3087 ENSG00000152804
2  ENSG00000178860 NA MSC musculin 9242 ENSG00000178860
3  ENSG00000163884 NA KLF15 Kruppel-like factor 15 28999 ENSG00000163884
4  ENSG00000177374 NA HIC1 hypermethylated in cancer 1 3090 ENSG00000177374
5  ENSG00000135363 NA LMO2 LIM domain only 2 (rhombotin-like 1) 4005 ENSG00000135363
6  ENSG00000151702 NA FLI1 Friend leukemia virus integration 1 2313 ENSG00000151702
7  ENSG00000134323 NA MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 4613 ENSG00000134323
8  ENSG00000107859 NA PITX3 paired-like homeodomain 3 5309 ENSG00000107859
9  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689
10  ENSG00000142599 NA RERE arginine-glutamic acid dipeptide (RE) repeats 473 ENSG00000142599
11  ENSG00000124440 NA HIF3A hypoxia inducible factor 3, alpha subunit 64344 ENSG00000124440
12  ENSG00000136870 NA ZNF189 zinc finger protein 189 7743 ENSG00000136870


Database:molecular function       Name:Ras guanyl-nucleotide exchange factor activity       ID:GO:0005088
C=112; O=4; E=0.53; R=7.48; rawP=0.0020; adjP=0.0378
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000116584 NA ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 9181 ENSG00000116584
2  ENSG00000163947 NA ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 50650 ENSG00000163947
3  ENSG00000126217 NA MCF2L MCF.2 cell line derived transforming sequence-like 23263 ENSG00000126217
4  ENSG00000088387 NA DOCK9 dedicator of cytokinesis 9 23348 ENSG00000088387


Database:molecular function       Name:nucleic acid binding transcription factor activity       ID:GO:0001071
C=1011; O=12; E=4.83; R=2.49; rawP=0.0028; adjP=0.0378
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000152804 NA HHEX hematopoietically expressed homeobox 3087 ENSG00000152804
2  ENSG00000178860 NA MSC musculin 9242 ENSG00000178860
3  ENSG00000163884 NA KLF15 Kruppel-like factor 15 28999 ENSG00000163884
4  ENSG00000177374 NA HIC1 hypermethylated in cancer 1 3090 ENSG00000177374
5  ENSG00000135363 NA LMO2 LIM domain only 2 (rhombotin-like 1) 4005 ENSG00000135363
6  ENSG00000151702 NA FLI1 Friend leukemia virus integration 1 2313 ENSG00000151702
7  ENSG00000134323 NA MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 4613 ENSG00000134323
8  ENSG00000107859 NA PITX3 paired-like homeodomain 3 5309 ENSG00000107859
9  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689
10  ENSG00000142599 NA RERE arginine-glutamic acid dipeptide (RE) repeats 473 ENSG00000142599
11  ENSG00000124440 NA HIF3A hypoxia inducible factor 3, alpha subunit 64344 ENSG00000124440
12  ENSG00000136870 NA ZNF189 zinc finger protein 189 7743 ENSG00000136870


Database:molecular function       Name:MAP kinase kinase kinase activity       ID:GO:0004709
C=20; O=2; E=0.10; R=20.94; rawP=0.0040; adjP=0.0480
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000142733 NA MAP3K6 mitogen-activated protein kinase kinase kinase 6 9064 ENSG00000142733
2  ENSG00000095015 NA MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 4214 ENSG00000095015


Database:molecular function       Name:ephrin receptor binding       ID:GO:0046875
C=24; O=2; E=0.11; R=17.45; rawP=0.0058; adjP=0.0626
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000105851 NA PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 5294 ENSG00000105851
2  ENSG00000064999 NA ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 23294 ENSG00000064999


Database:cellular component       Name:nucleus       ID:GO:0005634
C=5955; O=36; E=26.54; R=1.36; rawP=0.0167; adjP=0.5818
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000171552 NA BCL2L1 BCL2-like 1 598 ENSG00000171552
2  ENSG00000140830 NA TXNL4B thioredoxin-like 4B 54957 ENSG00000140830
3  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689
4  ENSG00000138386 NA NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 4664 ENSG00000138386
5  ENSG00000161896 NA IP6K3 inositol hexakisphosphate kinase 3 117283 ENSG00000161896
6  ENSG00000112576 NA CCND3 cyclin D3 896 ENSG00000112576
7  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864
8  ENSG00000168309 NA FAM107A family with sequence similarity 107, member A 11170 ENSG00000168309
9  ENSG00000166289 NA PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 79156 ENSG00000166289
10  ENSG00000099875 NA MKNK2 MAP kinase interacting serine/threonine kinase 2 2872 ENSG00000099875
11  ENSG00000151702 NA FLI1 Friend leukemia virus integration 1 2313 ENSG00000151702
12  ENSG00000134323 NA MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 4613 ENSG00000134323
13  ENSG00000155130 NA MARCKS myristoylated alanine-rich protein kinase C substrate 4082 ENSG00000155130
14  ENSG00000136870 NA ZNF189 zinc finger protein 189 7743 ENSG00000136870
15  ENSG00000197372 NA ZNF675 zinc finger protein 675 171392 ENSG00000197372
16  ENSG00000109906 NA ZBTB16 zinc finger and BTB domain containing 16 7704 ENSG00000109906
17  ENSG00000171970 NA ZNF57 zinc finger protein 57 126295 ENSG00000171970
18  ENSG00000147526 NA TACC1 transforming, acidic coiled-coil containing protein 1 6867 ENSG00000147526
19  ENSG00000177374 NA HIC1 hypermethylated in cancer 1 3090 ENSG00000177374
20  ENSG00000135363 NA LMO2 LIM domain only 2 (rhombotin-like 1) 4005 ENSG00000135363
21  ENSG00000197566 NA ZNF624 zinc finger protein 624 57547 ENSG00000197566
22  ENSG00000175866 NA BAIAP2 BAI1-associated protein 2 10458 ENSG00000175866
23  ENSG00000142599 NA RERE arginine-glutamic acid dipeptide (RE) repeats 473 ENSG00000142599
24  ENSG00000077684 NA PHF17 PHD finger protein 17 79960 ENSG00000077684
25  ENSG00000152804 NA HHEX hematopoietically expressed homeobox 3087 ENSG00000152804
26  ENSG00000178860 NA MSC musculin 9242 ENSG00000178860
27  ENSG00000136044 NA APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 55198 ENSG00000136044
28  ENSG00000028839 NA TBPL1 TBP-like 1 9519 ENSG00000028839
29  ENSG00000163884 NA KLF15 Kruppel-like factor 15 28999 ENSG00000163884
30  ENSG00000133056 NA PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 5287 ENSG00000133056
31  ENSG00000096060 NA FKBP5 FK506 binding protein 5 2289 ENSG00000096060
32  ENSG00000107859 NA PITX3 paired-like homeodomain 3 5309 ENSG00000107859
33  ENSG00000103037 NA SETD6 SET domain containing 6 79918 ENSG00000103037
34  ENSG00000136872 NA ALDOB aldolase B, fructose-bisphosphate 229 ENSG00000136872
35  ENSG00000064999 NA ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 23294 ENSG00000064999
36  ENSG00000124440 NA HIF3A hypoxia inducible factor 3, alpha subunit 64344 ENSG00000124440


Database:cellular component       Name:transcriptional repressor complex       ID:GO:0017053
C=61; O=2; E=0.27; R=7.36; rawP=0.0303; adjP=0.5818
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000109906 NA ZBTB16 zinc finger and BTB domain containing 16 7704 ENSG00000109906
2  ENSG00000136044 NA APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 55198 ENSG00000136044


Database:cellular component       Name:histone deacetylase complex       ID:GO:0000118
C=48; O=2; E=0.21; R=9.35; rawP=0.0194; adjP=0.5818
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000136044 NA APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 55198 ENSG00000136044
2  ENSG00000142599 NA RERE arginine-glutamic acid dipeptide (RE) repeats 473 ENSG00000142599


Database:cellular component       Name:nucleoplasm part       ID:GO:0044451
C=820; O=8; E=3.65; R=2.19; rawP=0.0292; adjP=0.5818
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000077684 NA PHF17 PHD finger protein 17 79960 ENSG00000077684
2  ENSG00000109906 NA ZBTB16 zinc finger and BTB domain containing 16 7704 ENSG00000109906
3  ENSG00000136044 NA APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 55198 ENSG00000136044
4  ENSG00000028839 NA TBPL1 TBP-like 1 9519 ENSG00000028839
5  ENSG00000099875 NA MKNK2 MAP kinase interacting serine/threonine kinase 2 2872 ENSG00000099875
6  ENSG00000135363 NA LMO2 LIM domain only 2 (rhombotin-like 1) 4005 ENSG00000135363
7  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689
8  ENSG00000142599 NA RERE arginine-glutamic acid dipeptide (RE) repeats 473 ENSG00000142599


Database:cellular component       Name:microtubule organizing center       ID:GO:0005815
C=486; O=6; E=2.17; R=2.77; rawP=0.0212; adjP=0.5818
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000135338 NA LCA5 Leber congenital amaurosis 5 167691 ENSG00000135338
2  ENSG00000155130 NA MARCKS myristoylated alanine-rich protein kinase C substrate 4082 ENSG00000155130
3  ENSG00000171552 NA BCL2L1 BCL2-like 1 598 ENSG00000171552
4  ENSG00000147526 NA TACC1 transforming, acidic coiled-coil containing protein 1 6867 ENSG00000147526
5  ENSG00000136872 NA ALDOB aldolase B, fructose-bisphosphate 229 ENSG00000136872
6  ENSG00000145632 NA PLK2 polo-like kinase 2 10769 ENSG00000145632


Database:cellular component       Name:cell leading edge       ID:GO:0031252
C=257; O=3; E=1.15; R=2.62; rawP=0.1071; adjP=0.6144
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000116584 NA ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 9181 ENSG00000116584
2  ENSG00000126217 NA MCF2L MCF.2 cell line derived transforming sequence-like 23263 ENSG00000126217
3  ENSG00000175866 NA BAIAP2 BAI1-associated protein 2 10458 ENSG00000175866


Database:cellular component       Name:PML body       ID:GO:0016605
C=75; O=2; E=0.33; R=5.98; rawP=0.0441; adjP=0.6144
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000099875 NA MKNK2 MAP kinase interacting serine/threonine kinase 2 2872 ENSG00000099875
2  ENSG00000109906 NA ZBTB16 zinc finger and BTB domain containing 16 7704 ENSG00000109906


Database:cellular component       Name:centrosome       ID:GO:0005813
C=376; O=4; E=1.68; R=2.39; rawP=0.0870; adjP=0.6144
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000155130 NA MARCKS myristoylated alanine-rich protein kinase C substrate 4082 ENSG00000155130
2  ENSG00000171552 NA BCL2L1 BCL2-like 1 598 ENSG00000171552
3  ENSG00000136872 NA ALDOB aldolase B, fructose-bisphosphate 229 ENSG00000136872
4  ENSG00000145632 NA PLK2 polo-like kinase 2 10769 ENSG00000145632


Database:cellular component       Name:cytosol       ID:GO:0005829
C=2372; O=15; E=10.57; R=1.42; rawP=0.0996; adjP=0.6144
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163947 NA ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 50650 ENSG00000163947
2  ENSG00000126217 NA MCF2L MCF.2 cell line derived transforming sequence-like 23263 ENSG00000126217
3  ENSG00000205268 NA PDE7A phosphodiesterase 7A 5150 ENSG00000205268
4  ENSG00000116584 NA ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 9181 ENSG00000116584
5  ENSG00000133056 NA PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 5287 ENSG00000133056
6  ENSG00000171552 NA BCL2L1 BCL2-like 1 598 ENSG00000171552
7  ENSG00000141744 NA PNMT phenylethanolamine N-methyltransferase 5409 ENSG00000141744
8  ENSG00000136872 NA ALDOB aldolase B, fructose-bisphosphate 229 ENSG00000136872
9  ENSG00000105851 NA PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 5294 ENSG00000105851
10  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689
11  ENSG00000175866 NA BAIAP2 BAI1-associated protein 2 10458 ENSG00000175866
12  ENSG00000003400 NA CASP10 caspase 10, apoptosis-related cysteine peptidase 843 ENSG00000003400
13  ENSG00000088387 NA DOCK9 dedicator of cytokinesis 9 23348 ENSG00000088387
14  ENSG00000095015 NA MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 4214 ENSG00000095015
15  ENSG00000124440 NA HIF3A hypoxia inducible factor 3, alpha subunit 64344 ENSG00000124440


Database:cellular component       Name:chromatin remodeling complex       ID:GO:0016585
C=128; O=2; E=0.57; R=3.51; rawP=0.1114; adjP=0.6144
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000136044 NA APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 55198 ENSG00000136044
2  ENSG00000142599 NA RERE arginine-glutamic acid dipeptide (RE) repeats 473 ENSG00000142599




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).